Search Results - pharmaceuticals

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Inhibitors of Transporters or Uptake of Monoaminergic Neurotransmitters

Background One form of medical treatment for depression and neuropathic pain features a dual inhibitor called Cymbalta. This drug is manufactured and marketed by Eli Lilly. Researchers at Oregon State University have discovered a very efficient way of synthesizing Synosutine, which is comparable to Cymbalta in limited in vitro and in vivo assay....

Published: 6/17/2024 | Inventor(s): James White, David Chan, David Wong, Rajan Juniku, Jongtae Yang

Keywords(s): Biomedical, pharmaceuticals

Category(s): Chemistry

Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...

Published: 9/12/2024 | Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

Treatment for Metabolic Syndrome and Obesity Related Diseases

Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...

Published: 8/4/2022 | Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio

Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes

Category(s): Therapeutics

New Drugs for Treatment of Type 1 Diabetes

Background Type 1 diabetes (T1D) is a life-threatening autoimmune disease that usually appears in childhood without warning. Current treatment options involve the administration of various insulin analogs and auxiliary therapies. The global market for T1D treatment is over $25 billion and growing. T1D is caused by the immune-mediated destruction...

Published: 6/10/2024 | Inventor(s): Siva Kolluri, Nancy Kerkvliet, Jit Chakravarty, Sebastian Bernales

Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes

Category(s): Therapeutics

Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials

Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...

Published: 5/23/2023 | Inventor(s): Chris Beaudry, Xiaojie Zhang

Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis

Category(s): Agricultural, Chemical, Therapeutics

Treatment for Hypertension

Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...

Published: 1/16/2023 | Inventor(s): Patrick Iversen, Andrew Annalora

Keywords(s): Hypertension, pharmaceuticals, Transplantation

Category(s): Therapeutics

Mouse Model for Insulin Resistance

Opportunity Description Oregon State University is SEEKING RESEARCH COLLABORATIONS or LICENSEES for pharmaceutical R&D, or obesity and diabetes research, to exploit A NEW TYPE 2 DIABETES MOUSE MODEL. Created by Oregon State University professor Chrissa Kioussi, the mouse model is a SKELETAL MUSCLE SPECIFIC PITX2 NULL MOUSE. Development of the mouse...

Published: 5/10/2021 | Inventor(s): Chrissa Kioussi

Keywords(s): Biotechnology, Diabetes, insulin resistance, pharmaceuticals, Type 2 Diabetes

Category(s): Biological Materials, Chemical, Medical Devices, Therapeutics

Antiproliferative Peptide Coibamide A

Background Cancer is one of the leading causes of morbidity and mortality worldwide, and the number of cases is expected to rise to 22 million over the next 2 decades. Modified natural products continue to be an important source for new drugs that address unmet needs in the battle against cancer. Technology Description Researchers at Oregon...

Published: 6/17/2024 | Inventor(s): Kerry Mcphail, Rebecca Medina, William Gerwick, Douglas Goeger, Susan Moobery, Todd Capson

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

Low Cost Methods for Producing Microchannel Process Technology

A manufacturing architecture that uses microchannel flow inserts to enable stamping and avoid photochemical etching Background Microchannel process technology is useful in a variety of applications including heat exchangers, solar cells, hydrogen storage, and chemical reactors. The surface-area-to-volume ratios of microchannels are as large as...

Published: 6/18/2024 | Inventor(s): Brian Paul, Samuel Brannon

Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Chemical Synthesis, Chemicals / Chemical Engineering, Electrical & Computer Engineering, Energy Storage, Heat exchangers, Heat Transfer, Manufacturing, Mechanical & Areospace Engineering, Metal Alloy, Microchannel, Mixing, Nanotechnology, pharmaceuticals, Physical Science, Physics / Applied Engineering, Process/Procedure, Reactor, Research Tools

Category(s): Device, Engineering, Medical Devices, Nanoscience & Microtechnologies, Physical Science, Research Tools, Sustainability & Cleantechnologies, Transportation

Natural dairy product biopolymer thickener from Lactococcus lactis Ropy352

Technology Description Natural polysaccharides produced by Ropy352 gives the yogurt a thick, smooth and sweet taste and are generally considered safe. Therefore, no other polysaccharides, like dextran, xanthan, and gellan from potentially pyrogenic inducing bacteria, are needed.Features & Benefits Natural and Generally Regarded As Safe (GRAS)Yogurt...

Published: 11/19/2024 | Inventor(s): Janine Trempy, Eric Knoshaug, William Sandine, Jeff Ahlgren, Karen Dierksen

Keywords(s): Agriculture, Food Science / Nutrition, Medical Science & Technologies, pharmaceuticals

Category(s): Agricultural, Chemistry, Research Tools

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