Search Results - pharmaceuticals

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Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin
Technology Description To produce a library of S. fungicidicus mutants, an in vitro transposon-based method was devised to randomly insert a selectable marker and oriT element in fosmid inserts carrying segments of the enramycin biosynthetic gene cluster and adjacent regions. This library of mutagenized fosmids was screened to identify specific disrupted...
Published: 3/13/2024   |   Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银
Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals
Category(s): Therapeutics
Treatment for Metabolic Syndrome and Obesity Related Diseases
Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...
Published: 8/4/2022   |   Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio
Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes
Category(s): Therapeutics
New Drugs for Treatment of Type 1 Diabetes
Background Type 1 diabetes (T1D) is a life-threatening autoimmune disease that usually appears in childhood without warning. Current treatment options involve the administration of various insulin analogs and auxiliary therapies. The global market for T1D treatment is over $25 billion and growing. T1D is caused by the immune-mediated destruction...
Published: 6/10/2024   |   Inventor(s): Siva Kolluri, Nancy Kerkvliet, Jit Chakravarty, Sebastian Bernales
Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes
Category(s): Therapeutics
Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials
Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...
Published: 5/23/2023   |   Inventor(s): Chris Beaudry, Xiaojie Zhang
Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis
Category(s): Agricultural, Chemical, Therapeutics
Treatment for Hypertension
Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...
Published: 1/16/2023   |   Inventor(s): Patrick Iversen, Andrew Annalora
Keywords(s): Hypertension, pharmaceuticals, Transplantation
Category(s): Therapeutics
Mouse Model for Insulin Resistance
Opportunity Description Oregon State University is SEEKING RESEARCH COLLABORATIONS or LICENSEES for pharmaceutical R&D, or obesity and diabetes research, to exploit A NEW TYPE 2 DIABETES MOUSE MODEL. Created by Oregon State University professor Chrissa Kioussi, the mouse model is a SKELETAL MUSCLE SPECIFIC PITX2 NULL MOUSE. Development of the mouse...
Published: 5/10/2021   |   Inventor(s): Chrissa Kioussi
Keywords(s): Biotechnology, Diabetes, insulin resistance, pharmaceuticals, Type 2 Diabetes
Category(s): Biological Materials, Chemical, Medical Devices, Therapeutics
Antiproliferative Peptide Coibamide A
Technology Description Researchers at Oregon State University have discovered, isolated, and purified a new antiproliferative compound, Coibamide A, which provides for a new and potent family of antiproliferative compounds. The peptidic molecular structure of Coibamide A presents a large number of possible combinations and permutations of component...
Published: 5/10/2021   |   Inventor(s): Kerry Mcphail, Rebecca Medina, William Gerwick, Douglas Goeger, Susan Moobery, Todd Capson
Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals
Category(s): Therapeutics
Low Cost Methods for Producing Microchannel Process Technology
Technology Description This manufacturing architecture uses microchannel flow inserts to eliminate the need for small photochemically-machined features, thereby enabling the use of stamping and, in turn, improving the material utilization and reducing the cost of compact, microchannel heat exchangers made from refractory alloys needed for high-temperature...
Published: 5/10/2021   |   Inventor(s): Brian Paul, Samuel Brannon
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Chemical Synthesis, Chemicals / Chemical Engineering, Electrical & Computer Engineering, Energy Storage, Heat exchangers, Heat Transfer, Manufacturing, Mechanical & Areospace Engineering, Metal Alloy, Microchannel, Mixing, Nanotechnology, pharmaceuticals, Physical Science, Physics / Applied Engineering, Process/Procedure, Reactor, Research Tools
Category(s): Device, Engineering, Medical Devices, Nanoscience & Microtechnologies, Physical Science, Research Tools, Sustainability & Cleantechnologies, Transportation
Inhibitors of Transporters or Uptake of Monoaminergic Neurotransmitters
Technology Description This technology is a simple and efficient way for synthesizing Synosutine, a drug to be potentially used to treat depression and neuropathic pain.Features & Benefits Much more efficient and quicker synthesis pathway than that for CymbaltaMore balanced inhibition of serotonin and norepinephrine transporters makes Synosutine...
Published: 2/8/2024   |   Inventor(s): James White, David Chan, David Wong, Rajan Juniku, Jongtae Yang
Keywords(s): Biomedical, pharmaceuticals
Category(s): Chemistry
Natural dairy product biopolymer thickener from Lactococcus lactis Ropy352
Technology Description Natural polysaccharides produced by Ropy352 gives the yogurt a thick, smooth and sweet taste and are generally considered safe. Therefore, no other polysaccharides, like dextran, xanthan, and gellan from potentially pyrogenic inducing bacteria, are needed.Features & Benefits Natural and Generally Regarded As Safe (GRAS)Yogurt...
Published: 3/17/2024   |   Inventor(s): Janine Trempy, Eric Knoshaug, William Sandine, Jeff Ahlgren, Karen Dierksen
Keywords(s): Agriculture, Food Science / Nutrition, Medical Science & Technologies, pharmaceuticals
Category(s): Agricultural, Chemistry, Research Tools
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