Search Results - therapeutics

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Next-Generation ROS Nanotherapy for Targeted Cancer Destruction

Produces complementary reactive oxygen species in tumors, enabling efficient tumor killing without external activation Background Conventional cancer treatments such as surgery, chemotherapy, and radiotherapy are often invasive, non-specific, and associated with systemic toxicity and long-term side effects. Emerging nanomedicine approaches improve...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Chao Wang

Keywords(s): breast cancer, chemodynamic therapy (CDT), Fenton reaction, ferrous, immuno-oncology, metal-organic framework (MOF), nanomedicine, oncology therapeutics, porphyrin, reactive oxygen species (ROS), Russell mechanism, solid tumor, tumor microenvironment, tumor suppression, tumor targeting, tumour microenvironment

Category(s): Therapeutics

Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

Next-Generation Photothermal Nanoagent for Safe Systemic Tumor Ablation

A resonance energy transfer (RET)–engineered nanoplatform enabling complete tumor ablation using near-infrared irradiation Background Photothermal therapy (PTT) uses NIR light to generate localized tumor heating. However, many systems require elevated laser power densities to achieve therapeutic temperatures, limiting translational feasibility....

Published: 4/3/2026 | Updated: 4/3/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Prem Singh

Keywords(s):

Category(s): Therapeutics, Medical Devices

Phage Bank for Selection of Personalized Therapeutic Treatments against Mycobacteria

A phage bank comprising lytic phages against mycobacteria, used to create phage cocktails for treatment of drug-resistant infections Background Non‑tuberculous mycobacteria (NTM) pathogens are extremely antibiotic resistant causing the most difficult-to-treat pulmonary infections in immunocompromised individuals such are cystic fibrosis (CF), bronchiectasis,...

Published: 8/4/2025 | Updated: 1/17/2025 | Inventor(s): Lia Danelishvili

Keywords(s):

Category(s): Biological Materials, Therapeutics

Selective Modulators of Ah-R to Treat Cancer

Synergistic compositions and method of using modulators of Ah-R activity and synergistic compounds to treat cancer Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. When activated by the binding of a wide range of both endogenous and exogenous small molecules, AhR signaling influences cellular outcomes in different...

Published: 8/4/2025 | Updated: 1/8/2025 | Inventor(s): Siva Kolluri, Bach Nguyen, Daniel Elson

Keywords(s):

Category(s): Therapeutics

Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment

Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....

Published: 1/12/2026 | Updated: 9/5/2024 | Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon

Keywords(s):

Category(s): Therapeutics

Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...

Published: 11/27/2024 | Updated: 12/7/2023 | Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

mRNA Therapeutic Against the SARS-CoV-2 Spike Protein

Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...

Published: 8/4/2025 | Updated: 12/16/2021 | Inventor(s): Gaurav Sahay, Anindit Mukherjee, Jeonghwan Kim

Keywords(s): antiviral, Drug, Drug Delivery, mRNA, mRNA carrier, mRNA delivery

Category(s): Therapeutics

Treatment for Metabolic Syndrome and Obesity Related Diseases

Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...

Published: 8/4/2025 | Updated: 12/15/2021 | Inventor(s): Jan Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio

Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes

Category(s): Therapeutics

Morpholino Oligomers to Prevent and Treat Coronavirus Infection

This technology licensing opportunity relates to antisense agents for treating or preventing a SARS-CoV-2 infection. The antisense agents are peptide-conjugated morpholino oligomers targeting pre-mRNA of a host (human) gene that encodes a protease. Some antisense agents included within the scope of this technology include agents previously shown to...

Published: 7/30/2025 | Updated: 11/24/2020 | Inventor(s): Hong Moulton, David Stein, Eva Bottcher-Friebershauser

Keywords(s): Morpholino, SARS-CoV-2, Therapeutic

Category(s): Therapeutics

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