Search Results - therapeutics

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mRNA Therapeutic Against the SARS-CoV-2 Spike Protein
Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...
Published: 12/16/2021   |   Inventor(s): Gaurav Sahay, Anindit Mukherjee, Jeonghwan Kim
Keywords(s): antiviral, Drug, Drug Delivery, mRNA, mRNA carrier, mRNA delivery
Category(s): Therapeutics
Treatment for Metabolic Syndrome and Obesity Related Diseases
Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...
Published: 12/15/2021   |   Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio
Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes
Category(s): Therapeutics
Morpholino Oligomers to Prevent and Treat Coronavirus Infection
This technology licensing opportunity relates to antisense agents for treating or preventing a SARS-CoV-2 infection. The antisense agents are peptide-conjugated morpholino oligomers targeting pre-mRNA of a host (human) gene that encodes a protease. Some antisense agents included within the scope of this technology include agents previously shown to...
Published: 11/24/2020   |   Inventor(s): Hong Moulton, David Stein, Eva Bottcher-Friebershauser
Keywords(s):  
Category(s): Therapeutics
Antisense Therapeutic Agents for Treatment of Covid-19
Technology Description This technology licensing opportunity relates to antisense agent compounds for treating or preventing a SARS-CoV-2 infection. A key feature of this technology is unique cell penetrating peptide and antisense oligomer (CPP-PMO) combinations that provide improved antiviral efficacy and reduced cytotoxicity. The compounds are oligomers...
Published: 9/9/2020   |   Inventor(s): David Stein, Hong Moulton, Kyle Rosenke, Heinrich Feldmann
Keywords(s): antisense, coronavirus, covid-19, Drug, SARS-CoV-2, Therapeutic
Category(s): Therapeutics
New Drugs for Treatment of Type 1 Diabetes
Technology Description Oregon State University is seeking a licensee to develop and commercialize a new family of compounds that target the Ah receptor for treatment of Type 1 Diabetes. The compounds are based on the parental compound 11-Cl-BBQ, the use of which is described PCT patent application No. US2015/057873, in U.S. patent No. 10,308,649, and...
Published: 6/23/2020   |   Inventor(s): Jit Chakravarty, Nancy Kerkvliet, Siva Kolluri, Sebastian Bernales
Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes
Category(s): Therapeutics
Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials
Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...
Published: 5/20/2020   |   Inventor(s): Chris Beaudry, Xiaojie Zhang
Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis
Category(s): Agricultural, Chemical, Therapeutics
Treatment for Hypertension
Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...
Published: 1/7/2020   |   Inventor(s): Patrick Iversen, Andrew Annalora
Keywords(s): Hypertension, pharmaceuticals, Transplantation
Category(s): Therapeutics
Enhancing Radiation for Treatment of Cancer
Technology Description This licensing and collaborative research opportunity relates to a synergistic treatment strategy for enhancing the therapeutic efficacy of radiotherapy (RT) via nMOF-mediated drug delivery and RT enhancement. nMOF containing the high-Z element Hf and the ligand 1,4-dicarboxybenzene (Hf-BDC) was synthesized and loaded with two...
Published: 1/7/2020   |   Inventor(s): Conroy Sun, Allison DuRoss, Megan Neufeld
Keywords(s): Cancer, Radiation, Radiotherapy
Category(s): Therapeutics
Synthetic Cephalotaxine Synthesis and New Anti-Cancer Compounds
Technology Description Oregon State University is seeking a licensee for an improved method to synthesize chemotherapeutic Homoharringtonine (HHT) that overcomes the need to use plant derived cephalotaxine. The synthetic method provides a high yield of chemically synthesized cephalotaxine as an HHT precursor and also enables the synthesis of novel...
Published: 6/14/2019   |   Inventor(s): Chris Beaudry, Xuan Ju
Keywords(s):  
Category(s): Biological Materials, Chemical, Therapeutics
Photoreactor for Treatment of Jaundice
Technology Description Oregon State University is seeking a licensee or research collaborator for development or commercialization of a microfluidic visible light photoreactor for the treatment of jaundice in neonatal patients. The device enables safe extracorporeal blood treatment, making it an excellent replacement for equally effective, yet risky,...
Published: 4/22/2019   |   Inventor(s): John Lahmann, Adam Higgins
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Bilirubin, Blood, hyperbilirubinemia, light, Medical Science & Technologies, Neonatal, Newborn, Photoreactor, Sepsis, treatment
Category(s): Medical Devices, Therapeutics, Engineering
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