Search Results - biotechnology

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Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...

Published: 6/17/2024 | Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

Shoot Inducing Genes for Improved Production of Transgenic Plants

This invention, using Agrobacterium gene clusters, enables passive regeneration of transgenic cells without the need for plant hormones Background For plants which are recalcitrant (difficult) to transform, poor performance is usually associated with inadequate DNA delivery or difficult regeneration response. There is a need for improved methods...

Published: 8/25/2023 | Inventor(s): Greg Goralogia, Steven Strauss

Keywords(s): Agrobacterium, Biotechnology, gene transfer, gene-edited, transgenic

Category(s): Agricultural

Mouse Model for Vitamin D Regulated Antimicrobial Peptide Expression

Technology Description Oregon State University is seeking collaborative research opportunities or licensees for a humanized mouse model for vitamin D regulated antimicrobial peptide expression. The developed animal model is a transgenic mouse that carries a 6.2 kb human genomic DNA that possess the cathelicidin antimicrobial peptide (CAMP) gene. Vitamin...

Published: 1/16/2023 | Inventor(s): Adrian Gombart

Keywords(s): Animal Model, Antimicrobial, Biotechnology, Vitamin D regulation

Category(s): Therapeutics, Biological Materials, Research Tools

Mouse Model for Insulin Resistance

Opportunity Description Oregon State University is SEEKING RESEARCH COLLABORATIONS or LICENSEES for pharmaceutical R&D, or obesity and diabetes research, to exploit A NEW TYPE 2 DIABETES MOUSE MODEL. Created by Oregon State University professor Chrissa Kioussi, the mouse model is a SKELETAL MUSCLE SPECIFIC PITX2 NULL MOUSE. Development of the mouse...

Published: 5/10/2021 | Inventor(s): Chrissa Kioussi

Keywords(s): Biotechnology, Diabetes, insulin resistance, pharmaceuticals, Type 2 Diabetes

Category(s): Biological Materials, Chemical, Medical Devices, Therapeutics

Fluidic devices with photo-actuated gates and re-patternable channels

Background Microfluidic devices are a popular means of analyzing minute quantities of samples and feature high-throughput sampling capabilities and suitability for providing highly controlled microreactor environments; however, many types of microfluidic devices and related fabrication approaches can be costly and require great effort and time to...

Published: 6/17/2024 | Inventor(s): Vincent Remcho, Jintana Nammoonnoy, Myra Koesdjojo

Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Biological & Environmental Engineering, Biomedical, Biotechnology, Chemicals / Chemical Engineering, Diagnostic, Medical Science & Technologies, Multiplexing, Nanotechnology, Physics / Applied Engineering, Research Tools

Category(s): Device, Chemical, Chemistry, Diagnostics, Engineering, Nanoscience & Microtechnologies, Research Tools

Antiproliferative Peptide Coibamide A

Background Cancer is one of the leading causes of morbidity and mortality worldwide, and the number of cases is expected to rise to 22 million over the next 2 decades. Modified natural products continue to be an important source for new drugs that address unmet needs in the battle against cancer. Technology Description Researchers at Oregon...

Published: 6/17/2024 | Inventor(s): Kerry Mcphail, Rebecca Medina, William Gerwick, Douglas Goeger, Susan Moobery, Todd Capson

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

Genetic incorporation of tetrazine amino acids and use in bioorthogonal ligations

Technology Description Ideal bioorthogonal reactions containing high reaction rates, high selectivity and high stability would allow for stoichiometric labeling of biomolecules in minutes and eliminate the need to washout excess labeling reagent. Currently no general method exists for controlled stoichiometric or sub-stoichiometric labeling of proteins...

Published: 6/18/2024 | Inventor(s): Ryan Mehl, Robert Blizzard

Keywords(s): Biological & Environmental Engineering, Biomedical, Biotechnology, Diagnostic, Labels, Protein Polymer Hybrids, Research Tools

Category(s): Diagnostics