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Fluidic devices with photo-actuated gates and re-patternable channels

Technology Description This patented technology (US 8,580,161) describes ways of controlling fluid movement in microfluidic devices and microwell plates. Fluid movement is achieved by controlling gating, valving, and permeation using light-actuated compounds such as a spiropyran. Prototypes have been tested in the lab and we are looking for a licensee...

Published: 5/10/2021 | Inventor(s): Vincent Remcho, Jintana Nammoonnoy, Myra Koesdjojo

Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Biological & Environmental Engineering, Biomedical, Biotechnology, Chemicals / Chemical Engineering, Diagnostic, Medical Science & Technologies, Multiplexing, Nanotechnology, Physics / Applied Engineering, Research Tools

Category(s): Device, Chemical, Chemistry, Diagnostics, Engineering, Nanoscience & Microtechnologies, Research Tools

Macromolecular Structure Determination without Crystallization

Technology Description This technology describes ways to determine 3D protein structure at atomic-resolution without crystallization and protein purification through laser-induced orientation of individual macromolecules.Features & Benefits No protein crystallization required so works for membrane proteinsNo derivatization of sample needed to solve...

Published: 9/15/2023 | Inventor(s): Joseph Beckman, Wei Kong, Valery Voinov, William Freund

Keywords(s): Research Tools

Category(s): Chemistry, Device, Engineering, Research Tools

Low Cost Methods for Producing Microchannel Process Technology

Technology Description This manufacturing architecture uses microchannel flow inserts to eliminate the need for small photochemically-machined features, thereby enabling the use of stamping and, in turn, improving the material utilization and reducing the cost of compact, microchannel heat exchangers made from refractory alloys needed for high-temperature...

Published: 5/10/2021 | Inventor(s): Brian Paul, Samuel Brannon

Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Chemical Synthesis, Chemicals / Chemical Engineering, Electrical & Computer Engineering, Energy Storage, Heat exchangers, Heat Transfer, Manufacturing, Mechanical & Areospace Engineering, Metal Alloy, Microchannel, Mixing, Nanotechnology, pharmaceuticals, Physical Science, Physics / Applied Engineering, Process/Procedure, Reactor, Research Tools

Category(s): Device, Engineering, Medical Devices, Nanoscience & Microtechnologies, Physical Science, Research Tools, Sustainability & Cleantechnologies, Transportation

Genetic incorporation of tetrazine amino acids and use in bioorthogonal ligations

Technology Description Ideal bioorthogonal reactions containing high reaction rates, high selectivity and high stability would allow for stoichiometric labeling of biomolecules in minutes and eliminate the need to washout excess labeling reagent. Currently no general method exists for controlled stoichiometric or sub-stoichiometric labeling of proteins...

Published: 3/19/2024 | Inventor(s): Ryan Mehl, Robert Blizzard

Keywords(s): Biological & Environmental Engineering, Biomedical, Biotechnology, Diagnostic, Labels, Protein Polymer Hybrids, Research Tools

Category(s): Diagnostics