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Chrissa
Kioussi investigates the molecular strategies responsible for organ development
and regeneration. Her work has uncovered roles of genes that regulate cell
fate, organ architecture and body homeostasis. She uses mouse models to understand the molecular
mechanisms and signals that embryos normally use to make muscle. These
strategies link regulated gene response to other cellular response systems during biological processes
and disease states, and will lead to therapeutic approaches for regenerative
medicine to cure cardiopathies,
myopathies and growth defects.
Representative
publications:
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Pax3: A paired domain gene as a regulator of PNS myelination. Kioussi, C.,
Gross, M. K. and Gruss, P. (1995). Neuron
15: 554-563.
•
Pitx2 regulates lung asymmetry, cardiac positioning, and pituitary and tooth
Morphogenesis. Kioussi, C., Lin C. R., O' Connell, S., Briata, P., Szeto, D.,
Liu, F., Izpisua-Belmonte, J.C. and Rosenfeld, M. G. (1999). Nature 401: 279-282.
•
Identification of a Wnt/Dvl/Pitx pathway mediating cell type specific
proliferation during development. Kioussi, C., Briata, P., Baek, S.H., Rose,
D., Hamblet, N. S., Herman, T., Oghi K.A., Lin C., Gleiberman, A., Wang, J.,
Brault, V., Ruiz-Lozano, P., Nhugen, H.D., Kemler, R., Glass, C.K.,
Wynshaw-Boris, A. and Rosenfeld, M.G. (2002).
•
Predicting Active Nodes in the Transcriptional Network Governing Neural Tube
Patterning. Kioussi, C., Shih, H.P., Loflin, J. and Gross, M.K. (2006). Proc Natl Acad Sci U S A 103(49):
18621-18626
• Cranial Muscle Defects of Pitx2 Mutants Result from Specification
Defects in the First Branchial Arch. Shih H.P., Gross M.K and Kioussi C.
(2007). Proc Natl Acad Sci U S A 104(14)
5907-5912.
• Pitx2-mediated cardiac outflow tract remodeling. Ma H.Y., Xu J., Eng
D., Gross M.K., Kioussi C. (2013) Dev Dyn. 242(5):456-68. doi: 10.1002/dvdy.23934.
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