Search Results - Therapeutics

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Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment

Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....

Published: 9/5/2024 | Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon

Keywords(s):

Category(s): Therapeutics

Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin

Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...

Published: 9/12/2024 | Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银

Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals

Category(s): Therapeutics

mRNA Therapeutic Against the SARS-CoV-2 Spike Protein

Background Vaccines have shown great efficacy against SARS-CoV-2, the pathogen of COVID-19; however, methods of treatment are required for patients suffering from COVID‑19. More than 15 million cases with over 600,000 deaths have resulted from the ongoing coronavirus disease 2019 (COVID-19). SARS-CoV-2, the pathogen of COVID-19, is a β-coronavirus...

Published: 8/4/2022 | Inventor(s): Gaurav Sahay, Anindit Mukherjee, Jeonghwan Kim

Keywords(s): antiviral, Drug, Drug Delivery, mRNA, mRNA carrier, mRNA delivery

Category(s): Therapeutics

Treatment for Metabolic Syndrome and Obesity Related Diseases

Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...

Published: 8/4/2022 | Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio

Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes

Category(s): Therapeutics

Morpholino Oligomers to Prevent and Treat Coronavirus Infection

This technology licensing opportunity relates to antisense agents for treating or preventing a SARS-CoV-2 infection. The antisense agents are peptide-conjugated morpholino oligomers targeting pre-mRNA of a host (human) gene that encodes a protease. Some antisense agents included within the scope of this technology include agents previously shown to...

Published: 5/26/2021 | Inventor(s): Hong Moulton, David Stein, Eva Bottcher-Friebershauser

Keywords(s):

Category(s): Therapeutics

Antisense Agents for Treating SARS-CoV-2 Infection

Background In December 2019, cases of an acute respiratory disease were reported from Wuhan, the capital of Hubei province in China. The number of infections increased rapidly and spread to other areas of China and on January 13th, 2020, the first case was reported outside of China. The causative agent was identified as a novel coronavirus (CoV)...

Published: 7/31/2023 | Inventor(s): David Stein, Hong Moulton, Kyle Rosenke, Heinrich Feldmann

Keywords(s): antisense, coronavirus, covid-19, Drug, SARS-CoV-2, Therapeutic

Category(s): Therapeutics

New Drugs for Treatment of Type 1 Diabetes

Background Type 1 diabetes (T1D) is a life-threatening autoimmune disease that usually appears in childhood without warning. Current treatment options involve the administration of various insulin analogs and auxiliary therapies. The global market for T1D treatment is over $25 billion and growing. T1D is caused by the immune-mediated destruction...

Published: 6/10/2024 | Inventor(s): Siva Kolluri, Nancy Kerkvliet, Jit Chakravarty, Sebastian Bernales

Keywords(s): Diabetes, pharmaceuticals, Therapeutic, Type 1 Diabetes

Category(s): Therapeutics

Substituted Phenols and Benzenes for Pharmaceuticals, Agrochemicals and Synthetic Materials

Technology Description This technology licensing opportunity is for novel phenol and benzene compounds with any number of substituents and complete positional selectivity. Synthesis of the compounds is achieved by a new synthetic method. The method provides a one-step conversion of readily available starting materials to give phenols with complete...

Published: 5/23/2023 | Inventor(s): Chris Beaudry, Xiaojie Zhang

Keywords(s): agrochemical, benzenes, chemistry, medicinal, organic, pharmaceuticals, phenols, polymer, substituted, synthesis

Category(s): Agricultural, Chemical, Therapeutics

Treatment for Hypertension

Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...

Published: 1/16/2023 | Inventor(s): Patrick Iversen, Andrew Annalora

Keywords(s): Hypertension, pharmaceuticals, Transplantation

Category(s): Therapeutics

Synthetic Cephalotaxine Synthesis and New Anti-Cancer Compounds

Technology Description Oregon State University is seeking a licensee for an improved method to synthesize chemotherapeutic Homoharringtonine (HHT) that overcomes the need to use plant derived cephalotaxine. The synthetic method provides a high yield of chemically synthesized cephalotaxine as an HHT precursor and also enables the synthesis of novel...

Published: 1/13/2023 | Inventor(s): Chris Beaudry, Xuan Ju

Keywords(s):

Category(s): Biological Materials, Chemical, Therapeutics

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