Search Results - drug+development

3 Results

Sort By:

Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)

Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...

Published: 5/9/2026 | Updated: 2/19/2026 | Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl

Keywords(s): antibody, architecture, assay, assay development, bacterial, bacterial expression system, binders, cancer, code, denaturing, diagnostic, drug development, enzymatic, epitope, expression platform, expression system, fusion, homogeneous, inclusion, isotopic, isotopic labeling, mass spectrometry, neurodegeneration, post-translational, protein, purification, reagent, recombinant, screening assays, structural biology

Category(s): Biological Materials

Peptide Inhibitors of Gonorrhoeae

Technology Description Antigonococcal peptide inhibitors of Neisseria gonorrhoeae that act against a non-conventional new target, nitrite reductase AniA, that is necessary for N. gonorrhoeae anaerobic respiration and biofilm formation. The anaerobic life style is an important state during disease and favored in biofilms, which form in cervical gonococcal...

Published: 8/4/2025 | Updated: 6/8/2017 | Inventor(s): Aleksandra Sikora, Konstantin Korotkov

Keywords(s): Antibiotics, Antimicrobial, Drug, Drug Development, Gonorrhea, Inhibitor, Microbiology, Peptide, Therapeutic

Category(s): Therapeutics, Vaccines