Technology Description
Oregon State University is seeking collaborative research opportunities or licensees for a humanized mouse model for vitamin D regulated antimicrobial peptide expression. The developed animal model is a transgenic mouse that carries a 6.2 kb human genomic DNA that possess the cathelicidin antimicrobial peptide (CAMP) gene. Vitamin D regulates the expression of the CAMP gene in both immune and epithelial barrier cells. This occurs via toll-like receptor signaling that activates the vitamin D pathway. This mechanism may explain the ability of vitamin D to boost the innate immune response and protect against infection.
Features & Benefits
Applications
Background of Invention
There is considerable evidence that vitamin D plays a role preventing infections, and that it may be useful as a treatment. The regulation of CAMP by vitamin D receptor is conserved in humans and non-human primates, but not in other mammals such as mice due to the lack of a vitamin D receptor response element. Thus, there is a need for a humanized mouse model to facilitate studies of vitamin D in preventing and treating infections.
Status
Available to license a biological material