Pactamycin Analogs Having Antibacterial, Antitumor, and Antimalarial Activity

Background
The global emergence of multi-drug resistant bacterial infections has resulted in enormous costs and has become a major threat to public health. About seventy percent of nosocomial infections are resistant to at least one commonly use antibiotic. Pactamycin is a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum. Its promising antitumor, antiviral, and anti-protozoal activities make pactamycin a promising parent compound for drug development that shows potent antimicrobial activity. Unfortunately, its development as a clinical compound has been hampered by its wide-ranging cytotoxicity. Moreover, its complex chemical structure has rendered its structural modification via synthetic organic chemistry difficult.

Technology Description
Patented (US8957251) pactamycin analogs having antibacterial, antitumor, antiviral and antimalarial activity. Also patented are biosynthetic methods of producing both the identified and additional new analogs. The identified analogs and methods of biosynthetic production provide a promising opportunity for discovery and development of new antibacterial, antimalarial, and antitumor drugs.