Search Results - Therapeutics

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Mouse Model for Vitamin D Regulated Antimicrobial Peptide Expression
Technology Description Oregon State University is seeking collaborative research opportunities or licensees for a humanized mouse model for vitamin D regulated antimicrobial peptide expression. The developed animal model is a transgenic mouse that carries a 6.2 kb human genomic DNA that possess the cathelicidin antimicrobial peptide (CAMP) gene. Vi...
Published: 7/6/2017   |   Inventor(s): Adrian Gombart
Keywords(s): Animal Model, Antimicrobial, Biotechnology, Vitamin D regulation
Category(s): Therapeutics, Biological Materials, Research Tools
Peptide Inhibitors of Gonorrhoeae
Technology Description Antigonococcal peptide inhibitors of Neisseria gonorrhoeae that act against a non-conventional new target, nitrite reductase AniA, that is necessary for N. gonorrhoeae anaerobic respiration and biofilm formation. The anaerobic life style is an important state during disease and favored in biofilms, which form in cervical gono...
Published: 6/8/2017   |   Inventor(s): Aleksandra Sikora, Konstantin Korotkov
Keywords(s): Antibiotics, Antimicrobial, Drug, Drug Development, Gonorrhea, Inhibitor, Microbiology, Peptide, Therapeutic
Category(s): Therapeutics, Vaccines
Inducing Coordinated Sexual Reproduction in Diatoms
Technology Description This technology describes a simple and efficient way of inducing coordinated sexual reproduction in two strains of the centric diatom Thalassiosira pseudonana, and two other centric diatom species, Thalassiosira weissflogii and Cyclotella cryptica. This technology is likely applicable across all diatoms. Induction of the sexu...
Published: 6/7/2017   |   Inventor(s): Eric Moore, Kimberly Halsey
Keywords(s): algae, Ammonia, Biofuels, Biological & Environmental Engineering, Climate Change, diatom, Microbiology, Oceanography, reproduction, sex
Category(s): Agricultural, Biological Materials, Research Tools, Sustainability & Cleantechnologies, Therapeutics
Anti-cancer Compounds
Technology Description This technology describes using compounds to induce cell death in Bcl-2 high-expressing cancer cells refractory to chemotherapeutic drugs but with minimal effects on normal cells. Further, the anti-cancer effect of these compounds is also confirmed in mouse xenograft studies. These results indicate that our compounds are effe...
Published: 4/10/2017   |   Inventor(s): Siva Kolluri, Prasad Kopparapu
Keywords(s): Cancer, metastatic tumor, small peptides
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
A Method to Treat Alzheimer’s, Heart and Liver Diseases
Technology Description This technology describes a process for the preparation of the tripeptide glutathione or its precursors to be delivered to the mitochondria for treating age-related conditions, toxicologic exposures, neurodegeneration, heart disease, and liver damage. More specifically, glutathione precursors and derivatives are coupled to a ...
Published: 3/28/2017   |   Inventor(s): Tory Hagen, Joseph Beckman, Pamela Beilby
Keywords(s): ALS, Alzheimer's, Antioxidant, Cancer, Liver disease, Medical Science & Technologies, Mitochondria, Neurodegenerative disease
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
Mouse Model for Insulin Resistance
Opportunity Description Oregon State University is SEEKING RESEARCH COLLABORATIONS or LICENSEES for pharmaceutical R&D, or obesity and diabetes research, to exploit A NEW TYPE 2 DIABETES MOUSE MODEL. Created by Oregon State University professor Chrissa Kioussi, the mouse model is a SKELETAL MUSCLE SPECIFIC PITX2 NULL MOUSE. Development of the m...
Published: 2/22/2017   |   Inventor(s): Chrissa Kioussi
Keywords(s): Biotechnology, Diabetes, insulin resistance, Pharmaceuticals, Type 2 Diabetes
Category(s): Biological Materials, Chemical, Medical Devices, Therapeutics
Marine Probiotic
Technology Description A newly identified marine bacterium strain useful as an aquaculture probiotic. Preliminary inhibition assays demonstrate that full cell culture and cell-free culture supernatant of the probiotic are sufficient to inhibit growth of the following Vibrio species: V.coralliilyticus (oysters and corals), V.parahaemolyticus (seafoo...
Published: 12/27/2016   |   Inventor(s): Carla Schubiger
Keywords(s): aquaculture, coral, food-borne disease, oyster, probiotic, wound-infection
Category(s): Agricultural, Biological Materials, Therapeutics
Engineering Tumor Organoids for Cancer Drug Testing
Technology Description Diskoid In Geometrically Micropatterned Extracellular matrix (DIGME), is a 3D tissue patterning solution that controls the shape of cell organoids, as well as the surrounding ECM. Together, DIGME generates complex microenvironment niches closely mimicking physiological conditions to support and guide the invasion of tumor org...
Published: 9/7/2016   |   Inventor(s): Bo Sun, Amani Alobaidi
Category(s): Diagnostics, Engineering, Therapeutics
Treatment for Neimann-Pick and Cholesterol Storage Disorders
Technology Description A combinatorial therapeutic approach to treating cholesterol storage disorders that may drastically reduce the dosage of HPβCD required for treatment of NPC. Proof-of-concept has been demonstrated in NPC mutant cells. The new therapeutic approach is based on the unexpected discovery that a lipid based molecule, itself pr...
Published: 6/23/2016   |   Inventor(s): Anna Brown, Gaurav Sahay
Keywords(s): 2-hydroxyl-propyl-β-cyclodextrin (HPβCD), Drug, Drug Delivery, Niemann Pick Type C (NPC), Pharmaceuticals
Category(s): Therapeutics
Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin
Technology Description To produce a library of S. fungicidicus mutants, an in vitro transposon-based method was devised to randomly insert a selectable marker and oriT element in fosmid inserts carrying segments of the enramycin biosynthetic gene cluster and adjacent regions. This library of mutagenized fosmids was screened to identify specific dis...
Published: 6/16/2016   |   Inventor(s): T. Mark Zabriskie, Xihou Yin
Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, Pharmaceuticals
Category(s): Therapeutics
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