Search Results - Therapeutics

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Anticancer Compounds
Technology Description Oregon State University seeks a licensee or collaborative research and development partner to further develop and commercialize a family of newly identified anti-cancer compounds. All inquiries are welcome. Preclinical studies have demonstrated that these compounds are effective in inhibiting viability of Ewing's sarcoma cell...
Published: 5/2/2018   |   Inventor(s): Mark Leid, Elahe Esfandiari
Keywords(s): Cancer, Sarcoma, Tumor
Category(s): Therapeutics
Cell Penetrating Peptides for Drug Delivery
Technology Description This is a new CPP drug delivery platform based on cell-penetrating self-assembling peptide nanomaterials (CSPNs). Through sequential ligation of peptide building blocks, our researchers created cell-penetrating self-assembling peptide nanomaterials (CSPNs) capable of translocating into cells. Atomic force microscopy revealed ...
Published: 3/29/2018   |   Inventor(s): Gaurav Sahay, Ashwani Narayana
Keywords(s): CSPN, Drug, Drug Delivery, Peptide
Category(s): Therapeutics
Treatment for Muscle Atrophy and for Enhancing Muscle Growth
Technology Description This technology licensing and collaboration opportunity is for an mRNA based therapeutic that provides for increased hepatic production of follistatin (FS). In vivo experiments demonstrate delivered mRNA accumulates in the liver, which results in an increase of FS in blood serum. Mouse studies demonstrate a subcutaneous injec...
Published: 2/1/2018   |   Inventor(s): Oleh Taratula, Canan Schumann, Olena Taratula, Adam (wathah) Alani
Keywords(s): atrophy, growth, mRNA carrier, mRNA delivery, muscle, Muscular Dystrophy, wasting
Category(s): Therapeutics
Synthesis of Iridium Nanoparticles
Technology Description This technology licensing and collaborative research opportunity relates to simple aqueous synthetic methods that produce uncapped stable colloidal iridium nanoparticles (IrNPs). The synthesized IrNPs are highly crystalline as observed by X-ray diffraction and high resolution TEM imaging. In vitro metabolic toxicity assays us...
Published: 12/11/2017   |   Inventor(s): Conroy Sun, Anna Brown, Gaurav Sahay
Keywords(s): Iridium, Nanoparticles, Synthesis
Category(s): Chemical, Therapeutics, Physical Science, Diagnostics, Materials Science
Mouse Model for Vitamin D Regulated Antimicrobial Peptide Expression
Technology Description Oregon State University is seeking collaborative research opportunities or licensees for a humanized mouse model for vitamin D regulated antimicrobial peptide expression. The developed animal model is a transgenic mouse that carries a 6.2 kb human genomic DNA that possess the cathelicidin antimicrobial peptide (CAMP) gene. Vi...
Published: 7/6/2017   |   Inventor(s): Adrian Gombart
Keywords(s): Animal Model, Antimicrobial, Biotechnology, Vitamin D regulation
Category(s): Therapeutics, Biological Materials, Research Tools
Peptide Inhibitors of Gonorrhoeae
Technology Description Antigonococcal peptide inhibitors of Neisseria gonorrhoeae that act against a non-conventional new target, nitrite reductase AniA, that is necessary for N. gonorrhoeae anaerobic respiration and biofilm formation. The anaerobic life style is an important state during disease and favored in biofilms, which form in cervical gono...
Published: 6/8/2017   |   Inventor(s): Aleksandra Sikora, Konstantin Korotkov
Keywords(s): Antibiotics, Antimicrobial, Drug, Drug Development, Gonorrhea, Inhibitor, Microbiology, Peptide, Therapeutic
Category(s): Therapeutics, Vaccines
Anti-cancer Compounds
Technology Description This technology describes using compounds to induce cell death in Bcl-2 high-expressing cancer cells refractory to chemotherapeutic drugs but with minimal effects on normal cells. Further, the anti-cancer effect of these compounds is also confirmed in mouse xenograft studies. These results indicate that our compounds are effe...
Published: 4/10/2017   |   Inventor(s): Siva Kolluri, Prasad Kopparapu
Keywords(s): Cancer, metastatic tumor, small peptides
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
A Method to Treat Alzheimer’s, Heart and Liver Diseases
Technology Description This technology describes a process for the preparation of the tripeptide glutathione or its precursors to be delivered to the mitochondria for treating age-related conditions, toxicologic exposures, neurodegeneration, heart disease, and liver damage. More specifically, glutathione precursors and derivatives are coupled to a ...
Published: 3/28/2017   |   Inventor(s): Tory Hagen, Joseph Beckman, Pamela Beilby
Keywords(s): ALS, Alzheimer's, Antioxidant, Cancer, Liver disease, Medical Science & Technologies, Mitochondria, Neurodegenerative disease
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
Mouse Model for Insulin Resistance
Opportunity Description Oregon State University is SEEKING RESEARCH COLLABORATIONS or LICENSEES for pharmaceutical R&D, or obesity and diabetes research, to exploit A NEW TYPE 2 DIABETES MOUSE MODEL. Created by Oregon State University professor Chrissa Kioussi, the mouse model is a SKELETAL MUSCLE SPECIFIC PITX2 NULL MOUSE. Development of the m...
Published: 2/22/2017   |   Inventor(s): Chrissa Kioussi
Keywords(s): Biotechnology, Diabetes, insulin resistance, Pharmaceuticals, Type 2 Diabetes
Category(s): Biological Materials, Chemical, Medical Devices, Therapeutics
Marine Probiotic
Technology Description A newly identified marine bacterium strain useful as an aquaculture probiotic. Preliminary inhibition assays demonstrate that full cell culture and cell-free culture supernatant of the probiotic are sufficient to inhibit growth of the following Vibrio species: V. coralliilyticus (oysters and corals), V. parahaemolyticus (seaf...
Published: 12/27/2016   |   Inventor(s): Carla Schubiger
Keywords(s): aquaculture, coral, food-borne disease, oyster, probiotic, wound-infection
Category(s): Agricultural, Biological Materials, Therapeutics
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