This technology describes ways to determine 3D protein structure at atomic-resolution without crystallization and protein purification through laser-induced orientation of individual macromolecules.
Features & Benefits
Background of Invention
Stage of development: 1). Successfully achieved laser induced alignment of a helium embedded phthalocyanine gallium chloride, which is more challenging than aligning a protein due to a smaller polarizability; 2). Fine tuning stage to deliver helium embedded macromolecule ions into orientation/diffraction zone for measurement. 3). Initial testing on well characterized protein after successful completion of stage 2.