Background of Invention
Kisspeptin is an important neuropeptide produced by distinct neuronal clusters in the Arcuate nucleus and anteroventral periventricular nuclei of the hypothalamus. It plays a key role in sexual differentiation of the brain, puberty onset, and metabolic control of fertility. It is required for reproduction. There is great interest in understanding the molecular mechanisms of kisspeptin transcriptional regulation, release, and control by sex steroid hormones. However, available cell lines do not represent the distinct populations of the Arcuate nucleus and AVPV, and fail to provide a model for studying their distinct estrogen responses.
Oregon State University professor Dr. Patrick Chappell has developed two immortalized cell lines representative of the neuroanatomical distinct Arcuate nucleus and anteroventral periventricular nuclei. The cell lines were derived from two functionally diverged populations of kisspeptin neurons in adult female mice, and each maintains a distinct response to estrogen exposure. The lines are a unique in vitro tool for investigating the molecular mechanisms of Kisspeptin transcriptional regulation, release, and control by sex steroid hormones.
Features & Benefits
Available for licensing as a biological material.