Kisspeptin Neuronal Cell Lines

Summary

 

Background of Invention

 

Kisspeptin is an important neuropeptide produced by distinct neuronal clusters in the Arcuate nucleus and anteroventral periventricular nuclei of the hypothalamus. It plays a key role in sexual differentiation of the brain, puberty onset, and metabolic control of fertility. It is required for reproduction. There is great interest in understanding the molecular mechanisms of kisspeptin transcriptional regulation, release, and control by sex steroid hormones. However, available cell lines do not represent the distinct populations of the Arcuate nucleus and AVPV, and fail to provide a model for studying their distinct estrogen responses.

 

Technology Description

 

Oregon State University professor Dr. Patrick Chappell has developed two immortalized cell lines representative of the neuroanatomical distinct Arcuate nucleus and anteroventral periventricular nuclei. The cell lines were derived from two functionally diverged populations of kisspeptin neurons in adult female mice, and each maintains a distinct response to estrogen exposure. The lines are a unique in vitro tool for investigating the molecular mechanisms of Kisspeptin transcriptional regulation, release, and control by sex steroid hormones.

 

Features & Benefits

 

  • Functionally diverged Kisspeptin neurons
  • Each cell line maintains its distinct response to estrogen exposure

 

Applications

 

  • Investigation of pubertal progression and reproduction in mammals
  • Potential therapeutic use for fertility treatment
  • Prospective use in endocrine-disrupting chemical research

 

Status

 

Available for licensing as a biological material.    

Patent Information:
Tech ID:
OSU-15-41
Category(s):
Research Tools
Contact:
Joe Christison
IP & Licensing Manager
Oregon State University
541-737-9016
joe.christison@oregonstate.edu
Inventors:
Patrick Chappell
Dakota Jacobs
Keywords:
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