Compound for maintaining pluripotency in ES cells

Summary

 

Technology Description

 

Small molecule compounds and methods for culturing ES cells that provide a means to maintain pluripotency without the use of costly leukemia inhibitory factor (LIF). Depending on the compounds used, the ES cells may remain pluripotent or ultimately be driven to an ectodermal or mesodermal fate. Pluripotency or differentiated state may be confirmed by using standard cell state biomarkers.

 

Features & Benefits

 

  • Simpler, more cost effective means to maintain ES cell pluripotency
  • Additional identified compounds drive cells towards ectoderm or mesoderm states.

 

Applications

 

  • Cell-based therapies
  • Regenerative medicine
  • Drug development

 

Background of Invention

 

Embryonic stem (ES) cells are pluripotent cells having the ability to self-renew and generate many types of specialized cells. ES cells are commonly used to improve detection of toxic compounds during development and testing of new drugs. They also carry great promise for regenerative medicine and cell based therapies; however, limited options for maintaining the pluripotency of ES cells or driving them to a desired differentiated state hamper discovery and development.

 

 

Status

 

Patent pending; available for exclusive licensing

 

Patent Information:
Tech ID:
OSU-15-42
Category(s):
Therapeutics
Contact:
Joe Christison
IP & Licensing Manager
Oregon State University
541-737-9016
joe.christison@oregonstate.edu
Inventors:
Chrissa Kioussi
Keywords:
Animal Model
Biotechnology
Drug
Pluripotency
Research Tools
Stem Cell
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