10-chloro-BBQ for the prevention of progression of type I diabetes



Technology Description


This technology describes using 10-chloro-7H-benzimidazo[2,1-a]benzo[de]Iso-quinolin-7-one (10-Cl-BBQ) and its analogs to treat type 1 diabetes, graft versus host disease and potentially other autoimmune diseases . In vivo studies in using non-obese diabetic (NOD) mice clearly demonstrated that low dose treatment during the early stages of type 1 diabetes prevented the autoimmune destruction of pancreatic beta cells and consequently prevented the progression and development full-blown type 1 diabetes. Additional studies have established the effectiveness of 10-Cl-BBQ in preventing the development of acute graft-vs-host disease, a debilitating immune-mediated condition associated with organ and bone-marrow transplantation.


Features & Benefits


  • no systemic immune suppression
  • favorable pharmacokinetics
  • no acute toxicity




  • type 1 diabetes
  • graft versus host disease
  • potentially other autoimmune diseases


Background of Invention


Lack of effective, non-toxic drug therapies for prevention and treatment of autoimmune diseases is a significant problem for the millions of people that suffer from such conditions. Accordingly, the present invention is a method of treating immune-mediated diseases comprising the step of administering a therapeutically effective amount of an aryl hydrocarbon receptor ligand. Patent pending and available for exclusive licensing.




Patent pending

Patent Information:
Tech ID:
Joe Christison
IP & Licensing Manager
Oregon State University
Nancy Kerkvliet
Siva Kolluri
Immune mediated diseases
Type 1 Diabetes
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