Joseph Beckman

A major research project in my laboratory is aimed at understanding how oxidative stress, superoxide dismutase, and zinc are involved in Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis (ALS). ALS is a dreadful disease caused by the unexplained death of motor neurons that control the movement of all voluntary muscles. We have only about 500,000 motor neurons at birth that cannot be replaced. Mutations in the antioxidant enzyme superoxide dismutase are the first identified cause of ALS. Our research indicates that the loss of zinc from superoxide dismutase is what causes motor neurons to die. We have shown that supporting cells in the spinal cord called astrocytes are key to understanding why the disease progresses.

TECHNOLOGIES
A radio-frequency-free simple to make retrofittable liquid chromatography compatible hybrid ECD/CID cell for mass spectrometry analysis
5th Amendment to A Radio-Frequency-Free Hybrid Electrostatic/ Magnetostatic Cell for Transporting, Trapping, and Dissociating Ions in Mass Spectrometers - Internal Electron Source Configurations
Macromolecular Structure Determination without Crystallization
A Method to Treat Alzheimer’s, Heart and Liver Diseases
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